Microbiome, Anxiety and Cognitive Orientation Study

Status unconfirmed

Conditions studied: Anxiety, Microbiome, Mood Disorders, Neurodegeneration, Depression

In brief

Mounting evidence shows that the gut microbiome plays an important role in communication within the gut-brain axis. However, the relationship between gut microbiota and their influence on anxiety is still not fully understood. Recent studies on mice found a specific microbe-produced molecule, 4-ethylphenyl sulfate (4EPS), can induce anxious behavior. 4EPS is produced by gut microbes in mice and humans. Research suggests higher 4EPS levels may strongly be associated with anxiety levels. However, anxiety is far more complicated than changes in a single molecule. There are many more factors to consider when it comes to anxiety, including various aspects of one's lifestyle and how humans perceive their environment (cognitive orientation). The primary research goal is to better understand the effects 4EPS has on human anxiety behavior and the role cognitive orientation has in connection to anxiety.

Key facts

Study ID

NCT05388630

Run by

Endominance

People needed

2000

Starts

2022-06-01

Expected to finish

2023-05-30

Last updated by the study team

2022-12-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Participants must be 18 years of age and older
• Participants must be able to read and write English
• Participants must be able to provide consent independently
• Participants must provide a legitimate postal address/P.O Box
• Participants must have access to a device such as a computer or a smartphone

You may not qualify if…

• Unable to provide a stool sample due to health status or functional impairment

Where it is running

• Endominance Inc. — Irvine, California, United States (enrolling)

Full record on ClinicalTrials.gov

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