International Registry of Acute Kidney Injury in Cirrhosis: The GLOBAL AKI Project
Completed
Conditions studied: Liver Cirrhosis, Acute Kidney Injury, Hepatorenal Syndrome
In brief
The aims of this study will be to identify the clinical characteristics, the management and the outcomes of acute kidney injury in patients with cirrhosis worldwide. Specific aims: 1. To establish the severity of AKI across different regions 2. To identify precipitants of AKI across different centers 3. To identify the phenotypes of AKI across different centers 4. To evaluate differences in the management of AKI across different centers and their impact on clinical outcomes 5. To assess outcomes of acute kidney injury (resolution of AKI, in-hospital mortality, 28-day mortality, 90-day mortality)
Key facts
- Study ID
- NCT05387811
- Run by
- Azienda Ospedaliera di Padova
- People needed
- 1456
- Starts
- 2022-07-01
- Expected to finish
- 2023-11-30
- Last updated by the study team
- 2024-01-30
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- a) Patients with cirrhosis admitted to hospital for the treatment of a complication of liver disease (ascites, gastrointestinal bleeding, hepatic encephalopathy, bacterial infections, jaundice, etc)
You may not qualify if…
- Age < 18 years old;
- Pregnancy;
- Hepatocellular carcinoma outside Milan criteria (i.e., a single lesion <5 cm or multiple lesions [maximum of three], the largest of which measures ≤ 3 cm);
- Extrahepatic malignancy other than non-melanoma skin cancer within last 5 years;
- Previously known severe extrahepatic diseases (e.g., chronic renal failure requiring hemodialysis, severe congestive heart disease [NYHA class ≥ 3]; severe chronic obstructive pulmonary disease [GOLD class ≥ 3], psychiatric disorders);
- Previous solid organ transplantation;
- HIV infection with CD4 ≤ 250/µL;
- Patients who cannot provide prior informed consent and no legal surrogate decision maker
Where it is running
- Hospital Nacional D.A. Carrion — Lima, Peru
- Medical University of Warsaw — Warsaw, Poland
- University of Moscow — Moscow, Russia
- Indiana University — Indianapolis, Indiana, United States
- Ochsner Medical Center — New Orleans, Louisiana, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Baylor University Medical Center — Dallas, Texas, United States
- University of Virginia — Charlottesville, Virginia, United States
- Hospital de Gastroenterología "Dr. Carlos Bonorino Udaondo" — Buenos Aires, Argentina
- Hospital Italiano — Buenos Aires, Argentina
- Hospital Nacional Prof. Alejandro Posadas — El Palomar, Argentina
- Universidad de Rosario — Rosario, Argentina
- Hospital Federal de Bonsoccesso — Rio de Janeiro, Brazil
- Universidad de Chile — Santiago, Chile
- Shanghai Jiao Tong University School of Medicine — Shanghai, China
- Hvidovre Hospital — Copenhagen, Denmark
- Ain Shams University — Cairo, Egypt
- Black Lion Hospital — Addis Ababa, Ethiopia
- Jean Minjoz University Hospital — Besançon, France
- Hospital Beaujon — Clichy, France
- University of Aachen — Aachen, Germany
- University Hospital Munich — Munich, Germany
- Hospital of Debrecen — Debrecen, Hungary
- Institute of Liver and Biliary Sciences — New Delhi, India
- IRCCS Azienda Ospedaliera-Universitaria di Bologna — Bologna, Italy
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.