CGM and Lifestyle Changes in Patients With Impaired Glucose Tolerance

Completed · Not applicable

Conditions studied: Impaired Glucose Tolerance, Prediabetes

In brief

The incidence of type 2 diabetes (T2D) in children is increasing, paralleling the rising incidence of obesity. Preventing children and adolescents from developing T2D is critical. The health benefits of lifestyle modifications are well documented in this population, but success rates are low. Obesity in children and adolescents increases the risk of not only T2D but other complications as well, such as hypertension, dyslipidemias and more. The investigators hypothesize that having real-time glucose data with the use of a continuous glucose monitor (CGM) in obese patients with impaired glucose tolerance will improve adherence to lifestyle modifications. As a result, a decrease in body mass index (BMI) is expected with subsequent improvement in insulin sensitivity, thus reducing risk of obesity-related complications later in childhood/adolescence and adulthood.

Key facts

Study ID

NCT05387551

Run by

Nemours Children's Clinic

People needed

12

Starts

2022-12-01

Expected to finish

2026-06-25

Last updated by the study team

2026-08-07

Who can join

Age: 10 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children 10 to <18 years old (i.e., before their 18th birthday)
• Impaired glucose tolerance based on standardized oral glucose tolerance test (OGTT) or fasting glucose per American Diabetes Association criteria,
• Overweight or obese (BMI ≥85th percentile for age/sex)
• Patients are pubertal, defined as females with breast Tanner stage II or above, or males with testicular volume ≥4 mL

You may not qualify if…

• Existing diagnosis of type 1 or type 2 diabetes
• Prepubertal
• Taking medications that affect insulin sensitivity (e.g.,chronic corticosteroids whether systemic or inhaled). Metformin allowed if stable dose.
• Patients and/or families not willing to wear the CGM for the duration of the study period or lack of compliance after recruitment

Where it is running

• Nemours Children's Clinic — Jacksonville, Florida, United States

Full record on ClinicalTrials.gov

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