Adaptive Optics Retinal Imaging in Inherited and Acquired Retinal Disorders

Recruiting now

Conditions studied: Genetic Disease, Inherited Disease

In brief

This is a Prospective Observational study. The aim of the study is to understand the underlying photoreceptor, retinal pigment epithelium or retinal vascular aberrations in inherited and acquired retinal disorders. The study would use adaptive optics (AO) technology to assist in-vivo visualization of these retinal structures and ascertain changes from normal. Further, by using the AO imaging in patients before and after treatments, this study aims to better understand the effect of various interventions and develop AO as an outcome measure in various retinal disorders.

Key facts

Study ID

NCT05386134

Run by

The Hospital for Sick Children

People needed

200

Starts

2022-06-13

Expected to finish

2033-06-13

Last updated by the study team

2026-04-28

Who can join

Age: 5 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Consent provided
• Aged 5 - 70 years
• Diagnosed with well documented retinal disorder
• Control group Inclusion Criteria:
• Subjects aged 5 years - 70 years with normal eye examination.
• Patients with strabismus and otherwise normal visual acuity and eye examination
• Patients with unilateral eye diseases such as cataract, with a normal eye exam in the fellow eye.

You may not qualify if…

• Inability of the subject to maintain a stable position while seated
• Uncontrolled nystagmus, trembling or movements of the eyes or the head
• Presence of cataract or any opacity in the front of the eye that obscures retinal imaging
• Any general disease such neurological disease which could affect vision and the retina.
• History of previous uveitis, glaucoma, previous intra-ocular surgery or photodynamic therapy
• High refractive errors (> +15D or < -15D) that cannot be corrected by the adaptive optics system.
• Patients who have a history of photosensitivity or take any medicine that cause photosensitivity as a side effect
• Patients who are aphakic after cataract surgery

Where it is running

• The Hospital for Sick Children — Toronto, Ontario, Canada (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.