Meaning-Centered Pain Coping Skills Training for Cancer Pain

Completed · Not applicable

Conditions studied: Advanced Solid Tumor, Pain

In brief

This study is a randomized controlled trial of a psychosocial pain management intervention called, Meaning-Centered Pain Coping Skills Training (MCPC). Patients with advanced solid tumor cancer and pain interference will be randomized to MCPC or a standard care control condition. Patient-reported outcomes will be assessed at baseline and 8- and 12-week follow-ups. The risk and safety issues in this trial are low and limited to those common to a psychosocial intervention (e.g., loss of confidentiality).

Key facts

Study ID

NCT05385965

Run by

Duke University

People needed

211

Starts

2023-02-09

Expected to finish

2026-05-08

Last updated by the study team

2026-05-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Stage IV solid tumor cancer diagnosis
• Eastern Cooperative Oncology Group (ECOG) performance status of 2 or lower
• At least one clinical pain severity rating > 0 out of 10 in past month
• At least moderate pain interference (8-item Patient-Reported Outcomes Measurement Information System [PROMIS] Pain Interference T-score >/= 55) in the past week at telephone screening
• Ability to speak and read in English
• Age >/= 18 years.

You may not qualify if…

• Significant cognitive impairment as indicated in medical chart or during telephone screening
• Serious untreated mental illness
• Primary brain cancer diagnosis
• Previous engagement in Pain Coping Skills Training or Meaning-Centered Psychotherapy
• Enrollment in hospice at screening

Where it is running

• Duke Cancer Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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