Utility of Biparametric MRI (Magnetic Resonance Imaging) as a Screening Tool for Prostate Cancer in a High-Risk Cohort

Recruiting now · Not applicable

Conditions studied: Prostate Cancer, Magnetic Resonance Imaging, Population at Risk

In brief

To determine whether using bpMRI in subjects who are at high risk of developing prostate cancer in conjunction with PSA will improve prostate cancer screening protocols.

Key facts

Study ID: NCT05384535
Run by: Northwell Health
People needed: 100
Starts: 2022-08-15
Expected to finish: 2028-10-31
Last updated by the study team: 2025-11-24

Who can join

Age: 40 and older, up to 55. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

PSA between 1.0 and 2.5 ng/dL
High risk for prostate cancer, i.e. Black or they have a first degree relative with history of prostate cancer (father, brother) or specific genetic syndromes i.e. BRCA 1/2, HOX B13, Lynch syndrome, ATM, CHEK2
Patient is willing to participated in prostate cancer screening
Patient is capable of giving informed consent

You may not qualify if…

Nodularity or firmness of prostate on exam
Patient has undergone a prior biopsy or prostate surgery
Patient is taking 5-alpha reductase inhibitors to manage benign prostatic hyperplasia, as this can significantly alter PSA levels.
Patient has a history of UTI or prostatitis in the preceding 6 months, as this can significantly alter PSA levels.
Patient has a contraindication to MRI, these include but are not limited to pacemakers, neurostimulator devices, metal cardiac valves, certain tattoos, or foreign bodies
Participants that experience claustrophobia, anxiety and/or vertigo when moved inside the scanner
The participant cannot tolerate lying flat for the study duration

Where it is running

Cynthia Knauer — Lake Success, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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