Serial Gut Microbiome and Bacterial Gene Markers Changes After Endoscopic Resection of Colorectal Advanced Neoplasia

Recruiting now

Conditions studied: Colorectal Cancer, Colorectal Neoplasms, Colorectal Adenoma

In brief

The investigators hypothesize that gut microbiome composition and the four bacterial gene markers (M3) show dynamic changes after endoscopic resection of advanced neoplasia, some key bacteria are associated with restoration of gut microbiome after endoscopic resection.

Key facts

Study ID

NCT05381792

Run by

Chinese University of Hong Kong

People needed

50

Starts

2022-09-01

Expected to finish

2024-12-15

Last updated by the study team

2024-08-27

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects require endoscopic resection (e.g. endoscopic mucosal resection or endoscopic submucosal dissection) for advanced adenoma or early-stage colorectal cancer;
• Aged 18-90 years old;
• Written informed consent obtained.

You may not qualify if…

• Absolute contraindications to colonoscopy (e.g. perforation, intestinal obstruction, unstable cardiopulmonary status);
• Contraindications to endoscopic resection (e.g. active gastrointestinal bleeding, uninterrupted anticoagulation or dual antiplatelets);
• Known pregnancy or lactation;
• Advanced comorbid conditions (defined as American Society of Anesthesiologists grade 4 or above);

Where it is running

• Prince of Wales Hospital — Shatin, New Territories, Hong Kong (enrolling)

Full record on ClinicalTrials.gov

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