CHART Study of Coronary CT Angiography in Coronary Artery Disease
Recruiting now
Conditions studied: Coronary Artery Disease
In brief
In a cohort of patients referred to coronary computed tomography angiography (CCTA), the investigators aim: 1. To describe the natural history of the coronary atherosclerotic plaque development and progression or regression, as well as the plaque characterization and phenotypes over time by CCTA among deferred coronary lesions 2. To explore the precursors of plaques leading to acute coronary syndrome (ACS) or chronic coronary syndrome (CCS) in deferred coronary lesions 3. To investigate prognostic implication of qualitative and quantitative plaque analysis of stenosis and plaque features, disease patterns, hemodynamic parameters, and fat metrics on CCTA along with physiologic assessment 4. To investigate the effects of different treatment strategies according to stenosis and plaque features, fat metrics on CCTA along with physiologic assessments.
Key facts
- Study ID
- NCT05380622
- Run by
- Shanghai Zhongshan Hospital
- People needed
- 5000
- Starts
- 2015-01-01
- Expected to finish
- 2030-12-31
- Last updated by the study team
- 2022-05-25
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with an indication for CCTA.
- Qualified patients who have signed a written informed consent form.
You may not qualify if…
- Left ventricular ejection fraction < 35%
- Acute ST-elevation myocardial infarction within 72 hours or previous coronary artery bypass graft surgery
- Abnormal epicardial coronary flow (TIMI flow < 3)
- Planned coronary artery bypass graft surgery after diagnostic angiography
- Poor quality of CCTA or other reasons by core lab that are unsuitable for plaque, physiological or fat analysis
- Patients with a stent in the target vessel
Where it is running
- Shanghai Zhongshan Hospital — Shanghai, China (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.