Metabolic Mechanisms Induced by Enteral DHA and ARA Supplementation in Preterm Infants

Recruiting now · Not applicable

Conditions studied: Premature

In brief

A comprehensive analysis of the impact of exogenous enteral DHA and ARA supplementation on lipid metabolism including the production of downstream derived mediators and how this impacts important biological pathways such as metabolism, inflammation, and organogenic factors.

Key facts

Study ID

NCT05380401

Run by

The University of Texas Health Science Center at San Antonio

People needed

328

Starts

2023-03-09

Expected to finish

2028-04-01

Last updated by the study team

2025-09-24

Who can join

Age: any, up to 1. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• born between 25 0/7 and 29 6/7 weeks of gestation
• less than 48 hours of age at first lipid dose (The cohort is defined by gestational age rather than birth weight to avoid an over-represented sample of growth-restricted infants in birth weight defined cohorts.)

You may not qualify if…

• serious congenital anomalies
• conditions at birth that will require surgery prior to discharge
• imminent death such that withdrawal of intensive care support is anticipated within the first 72 hours after birth

Where it is running

• University of California, Los Angeles (UCLA) — Los Angeles, California, United States (enrolling)
• Yale New Haven Hospital — New Haven, Connecticut, United States (enrolling)
• Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois, United States (enrolling)
• Northwestern University — Chicago, Illinois, United States (enrolling)
• Weill Cornell Medicine — New York, New York, United States (enrolling)
• University Health System — San Antonio, Texas, United States (enrolling)
• University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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