Personalized Cancer Stem Cell High-Throughput Drug Screening for Glioblastoma

Recruiting now · Early Phase 1

Conditions studied: Newly Diagnosed Glioblastoma

In brief

Proposed treatment of subjects with newly diagnosed glioblastoma with novel personalized drug regimens identified to be effective in vitro using cancer stem cells derived from their individual tumors, alongside standard of care radiation and TMZ.

Key facts

Study ID

NCT05380349

Run by

Swedish Medical Center

People needed

10

Starts

2024-04-19

Expected to finish

2027-12-01

Last updated by the study team

2025-05-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histological diagnosis of GBM (WHO grade 4)
• Subjects ≥18 years of age
• Patients must have a life expectancy of >6 months
• Patients must have a surgically accessible tumor with the intent for a gross or near total resection of the tumor mass (GBM, WHO grade 4)
• Patients must have a KPS rating of ≥70
• Patients should not have received any prior systemic anti-cancer therapy
• Patients must be negative for HIV, Hepatitis B and C
• Baseline hematologic studies and chemistry and coagulation profiles must meet the following criteria:
• Hemoglobin (Hgb)> 8 g/dL
• Absolute Neutrophil Count (ANC) > 1,000/mm3
• Platelet count > 100,000/mm3
• Creatinine < 2 mg/dL
• Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) < 3x upper limit of normal (ULN)

You may not qualify if…

• Metastatic disease
• Diseases or conditions that obscure toxicity or dangerously alter drug metabolism
• Serious intercurrent medical illness
• Inadequately controlled hypertension
• History of myocardial infarction or unstable angina within 6 months
• History of stroke or transient ischemic attack within 6 months

Where it is running

• Swedish Medical Center — Seattle, Washington, United States (enrolling)

Full record on ClinicalTrials.gov

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