Neuroinflammation and Alzheimer's Pathology in POCD

Status unconfirmed

Conditions studied: Post-Operative Confusion, Neuroinflammatory Response, Alzheimer Disease

In brief

The purpose of this project is to investigate the role of both neural inflammation and pre-existing neurodegenerative pathology in the risk and pathogenesis of post-operative cognitive dysfunction (POCD). To achieve this goal, the investigators will combine blood and cerebrospinal fluid (CSF) sampling, standardized cognitive tests, and dynamic neurophysiological markers of cortical network dysfunction in the form of event-related potentials (ERPs), to assess the link between neurodegeneration and neuroinflammation in the pathogenesis of POCD.

Key facts

Study ID

NCT05378659

Run by

University of Tennessee Graduate School of Medicine

People needed

120

Starts

2021-11-01

Expected to finish

2022-09-30

Last updated by the study team

2022-05-18

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Males and females 60 years or older in age
• Subjects scheduled to undergo TKA
• Fluent and literate in English
• Able to give consent for themselves based upon the MacArthur Competence Assessment Tool for Clinical Research
• Able to have a subarachnoid block with only intravenous sedation

You may not qualify if…

• Less than 60 years of age
• Cognitively impaired to the point where they are unable to give consent for themselves
• Blindness or partial blindness
• Pre-existing neurodegenerative conditions
• Contraindication for subarachnoid block and/or requiring general anesthesia

Where it is running

• Robert M Craft — Knoxville, Tennessee, United States (enrolling)

Full record on ClinicalTrials.gov

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