Comparing the Efficacy of Surgery Staging and Image Staging of Locally Advanced Cervical Cancer

Recruiting now · Not applicable

Conditions studied: Locally Advanced Cervical Cancer

In brief

The study is a domestic multicenter, prospective, non-randomized controlled concurrent trial. It will be assessed whether surgery staging on locally advanced cervical cancer is superior to image staging for improving progression-free survival and overall survival.

Key facts

Study ID

NCT05378087

Run by

Chongqing University Cancer Hospital

People needed

1956

Starts

2022-06-27

Expected to finish

2032-12-31

Last updated by the study team

2023-08-31

Who can join

Age: 18 and older, up to 75. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• The patients with good compliance, voluntarily signed the informed consent form and participated in the study.
• Histopathology: squamous cell carcinoma, adenocarcinoma, adenosquamous cell carcinoma
• Stage (FIGO2018): IB3, IIA2, IIB-IVA;
• ECOG score: 0 \~ 1;
• The expected survival >6 months;
• The result of a pregnancy test (serum or urine) within seven days must be negative for women of childbearing age, who must take contraception during the trial.

You may not qualify if…

• Activity or uncontrol severe infection;
• Liver cirrhosis or other decompensated liver disease;
• A history of immune deficiency, including HIV positive or a congenital immunodeficiency disease;
• Chronic renal insufficiency or renal failure;
• Other malignancies were diagnosed within five years or needed treatments;
• Myocardial infarction, severe arrhythmia and congestive heart failure with grade ≥2 (New York heart association);
• The CT/MRI/PET/CT show that the para-aortic lymph nodes are positive;
• A history of pelvic artery embolization;
• A history of pelvic radiotherapy;
• A history of partial hysterectomy or radical hysterectomy;
• A history of severe allergic reaction to platinum drugs;
• The drugs for the treatment of concomitant disease seriously impaired liver or kidney function, such as tuberculosis;
• Patients who cannot understand the research regimen and refuse to sign the informed consent form;
• Other concomitant diseases or special conditions seriously endanger the patient's health or interfere with the trial.

Where it is running

• Chongqing University Cancer Hospital — Chongqing, Chongqing Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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