Curcumin, Resveratrol, and Stinging Nettle as Treatments for GWI

Completed · Not applicable · Has a placebo group

Conditions studied: Gulf War Illness

In brief

This project's objective is to identify effective treatments for Gulf War Illness (GWI). The project tests three potential treatments: curcumin, stinging nettle, and resveratrol. The project uses a decentralized clinical trial (DCT) design in which individuals can participate from anywhere in the United States. Recruitment efforts will be designed to obtain a geographically and demographically diverse study sample.

Key facts

Study ID

NCT05377242

Run by

University of Alabama at Birmingham

People needed

390

Starts

2023-05-31

Expected to finish

2026-06-22

Last updated by the study team

2026-06-29

Who can join

Age: 45 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meets Kansas GWI Case Definition
• Meets CDC GWI Case Definition
• Able to commit to a 10-month study

You may not qualify if…

• Currently involved in an experimental treatment study
• Abnormal liver function values
• Abnormal kidney function values
• Currently pregnant
• Blood clotting disorder (contraindicated with all three botanicals)
• Reported diagnosis of diabetes with an A1C greater than 9
• The use of contraindicated medications (see below):
• Anticoagulant medications (such as warfarin, heparin, etc.)
• Lithium
• Tacrolimus (Prograf)
• Cancer medications (Alkylating agents, antitumor antibiotics, Topoisomerase I inhibitors, Tamoxifen)

Where it is running

• The University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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