FMT in Uncomplicated Diverticulitis
Running, not enrolling · Early Phase 1
Conditions studied: Diverticulitis, Uncomplicated Diverticular Disease
In brief
Fecal Microbiota Transplantation (FMT) is an established treatment for Clostridium difficile (C. diff) infection refractory to medical management. As C. diff infection usually arises due to significant disturbances in the gut microbiome, FMT is typically performed to restore a healthy microbiome among affected patients who have failed other treatments. Diverticulitis is a major, and often recurrent, source of morbidity in the U.S for which antibiotics and surgical resection constitute the only treatment options to date. Although alterations of the intestinal microbiome have also been shown among patients with diverticular disease, research on FMT in diverticulitis is sparse. The intended goal of this project is to determine the feasibility, effectiveness and safety of FMT in the treatment of uncomplicated diverticulitis, using clinical outcomes and microbiome analyses.
Key facts
- Study ID
- NCT05373784
- Run by
- Justin Maykel
- People needed
- 10
- Starts
- 2024-03-15
- Expected to finish
- 2026-12-30
- Last updated by the study team
- 2026-05-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
Where it is running
- UMASS Memorial Medical Center — Worcester, Massachusetts, United States
Full record on ClinicalTrials.gov
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