Delirium and Neuropsychological Recovery Among Emergency General Surgery Survivors

Running, not enrolling · Not applicable

Conditions studied: Delirium

In brief

This study will evaluate the usefulness of the Urgent and Emergency Surgery (UES) Delirium Recovery Model. It is hypothesized that the cognitive, physical and psychological recovery of older UES delirium survivors will be improved through the use of the DANE Recovery Model. Participants can expect to be on the study for 18 months.

Key facts

Study ID

NCT05373017

Run by

University of Wisconsin, Madison

People needed

528

Starts

2023-02-13

Expected to finish

2027-06-30

Last updated by the study team

2026-07-07

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult age 65 years and older
• Admitted to one of the participating hospitals
• Undergone an abdominal orthopedic, skin, or vascular surgery in an emergency or unplanned fashion
• English-speaking
• Able to provide consent or have a legally authorized representative to provide consent
• Access to a telephone or an internet connected computer or smart device
• Discharged to home or sub-acute rehabilitation
• At least one episode of delirium or subsyndromal delirium, i.e. screen positive on at least one out of the four items on the Confusion Assessment Method-ICU (CAM-ICU) in the period prior to discharge from acute care.

You may not qualify if…

• A self-reported diagnosis of cancer with short life expectancy
• A history of dementing illnesses and other neurodegenerative disease such as Alzheimer's disease (AD), Parkinson disease, or vascular dementia, or current prescription of anti-dementia medication, or ruled out by Functional Activities Questionnaire (FAQ) score defining dementia; a history of significant traumatic brain injury
• Acute or subacute neurologic deficit expected to prevent independent living after hospital discharge, e.g., a history of a significant traumatic brain injury
• Have any spinal cord injury with persistent neurologic deficit at the time of study enrollment
• Incarcerated or homeless at the time of study enrollment
• Acquired neurologic injury (stroke, traumatic brain injury, cerebral edema/swelling, anoxic brain injury, or any other acute/subacute severe neurologic deficit) as the admitting diagnosis or a new event during the course of hospitalization (confirmed by EMR)
• A history of bipolar disorder or schizophrenia (confirmed by EMR)

Where it is running

• SwedishAmerican Hospital — Rockford, Illinois, United States
• Indiana University — Indianapolis, Indiana, United States
• University of Wisconsin — Madison, Wisconsin, United States
• Meriter Hospital — Madison, Wisconsin, United States
• East Madison Hospital — Madison, Wisconsin, United States
• Medical College of Wisconsin — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

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