Efficacy and Safety of Mirabegron in Intracerebral Hemorrhage

Recruiting now · Phase 2

Conditions studied: Intracerebral Haemorrhage

In brief

Intracerebral hemorrhage (ICH) accounts for 10-15% of all strokes without effective pharmacological treatment. Inflammation following ICH contributes to barrier disruption and peri-hematoma edema, leading to deterioration of neurological function. Preclinical evidence suggests that bone marrow hematopoietic stem and progenitor cells (HSPCs) are swiftly activated after ICH. Thereafter, these HSPCs produce an increased output of anti-inflammatory monocytes as an endogenous protective mechanism. Stimulation of β3 adrenergic receptor using selective agonists promotes the production of anti-inflammatory monocytes in bone marrow, and thereby reduces neuroinflammation, brain edema and neurological deficits. This study is to assess the safety and efficacy of a β3 adrenergic receptor agonist Mirabegron as a potential treatment option in ICH patients.

Key facts

Study ID

NCT05369351

Run by

Tianjin Medical University General Hospital

People needed

25

Starts

2024-01-17

Expected to finish

2026-11-10

Last updated by the study team

2025-05-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female patients aged above 18 years old.
• The volume of the hematoma is 5-30 ml (including the cerebral cortex; Putamen, thalamus, caudate nucleus and related deep tracts; Cerebellar hemorrhage), which determined by CT scan.
• The onset of cerebral hemorrhage symptoms or the time from last normal to detection is not more than 72 hours.
• Patients with Glasgow Coma Scale (GCS) score ≥6 and < 12.
• Before the onset of the disease, function was independent and mRS score<1.
• Able and willing to sign written informed consent and comply with the requirements of the research protocol.

You may not qualify if…

• Multifocal cerebral hemorrhage, brain stem hemorrhage, or ventricular hemorrhage.
• Secondary cerebral hemorrhage caused by aneurysm, brain tumor, arteriovenous malformation, thrombocytopenia, coagulation disorder, traumatic brain injury, etc.
• Patients who require hematoma removal surgery or other emergency surgical interventions (such as decompressive craniectomy), or who are critically ill and close to death.
• Patients who interfere with drug use due to nausea or vomiting.
• Combined with the following conditions that preclude participation in the study due to other systemic diseases: Severe hepatic or renal impairment, atrial fibrillation or tachycardia, pulmonary infection, severe urinary tract infection, severe urinary tract obstruction, medically uncontrolled hypertension (systolic blood pressure ≥180mmHg or diastolic blood pressure ≥110mmHg), pregnant and lactating women, and a history of malignant tumors within 5 years.

Where it is running

• Tianjin Medical University General Hospital — Tianjin, Tianjin Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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