Air Pollution and Development in the Boricua Youth Study

Enrolling by invitation · Not applicable

Conditions studied: Pollution; Exposure, Neurodevelopmental Disorders

In brief

This study seeks to understand the relationship between prenatal maternal air pollution exposure and offspring risk for ADHD and examine two potential -modifiable- mechanisms: prenatal maternal inflammation and offspring sleep problems. We will employ a longitudinal neuroimaging study design and leverage a well-characterized intergenerational cohort of Puerto Ricans to address prior literature's limitations. This will be the first study to use infant neuroimaging to disassociate the effects of prenatal pollution exposure from those of postnatal pollution exposure, adversity and disadvantage, and offspring genetic risk for ADHD.

Key facts

Study ID: NCT05368493
Run by: New York State Psychiatric Institute
People needed: 182
Starts: 2023-01-23
Expected to finish: 2028-06-01
Last updated by the study team: 2026-08-06

Who can join

Age: 1 and older, up to 11. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Having been enrolled in the BYS-ECHO birth cohort (parent study).
Speaks English or Spanish.
Having a parent that is eligible to participate, based on criterial detailed below, and agrees to participation.
One parent must speak English or Spanish.

You may not qualify if…

Having serious neurological disorder, excluding ASD (e.g., seizure disorder).
MRI contraindications (irremovable metal in body like braces, pacemakers).
Claustrophobia.
Having a parent that is not competent to consent (e.g., severe intellectual disability would have triggered exclusion) or under 18 years of age.

Where it is running

New York State Psychiatric Institute — New York, New York, United States
University of Puerto Rico — San Juan, Puerto Rcio, Puerto Rico

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.