The Efficacy of Botulinum Toxin vs. Corticosteroid for the Treatment of Refractory Plantar Fasciitis

Completed · Phase 2/Phase 3

Conditions studied: Plantar Fasciitis

In brief

This single-blinded, randomized-controlled trial compares the efficacy of ultrasound-guided onabotulinumtoxinA (BTX-A) injections to the flexor digitorum brevis with current standard of care corticosteroid injections to the plantar fascia for the treatment of refractory plantar fasciitis in patients that have failed six weeks of non-operative treatment.

Key facts

Study ID

NCT05367271

Run by

Western Institute for Veterans Research

People needed

62

Starts

2022-08-23

Expected to finish

2024-09-13

Last updated by the study team

2025-04-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosed increased pain when pressure applied at the medial calcaneal tubercle
• X-ray negative for calcaneal fractures or tumors
• Patient with plantar fasciitis who have failed 6 weeks of non-operative treatment

You may not qualify if…

• Prior botulinum toxin injections in the plantar fascia
• Any botulinum toxin injections in the past 3 months
• Cortisone injection in the plantar fascia in the previous 3 months
• Previous surgery on the plantar fascia
• Active workers compensation claim for plantar fasciitis
• Active infection or fever
• Botox or steroid allergy
• Pregnancy
• Current other treatment specific to the plantar fascia or intent to undergo during the trial

Where it is running

• VA Salt Lake City Health Care System — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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