Neoadjuvant Chemotherapy Followed by Chemoradiation Versus Chemoradiation for Stage IIIC Cervical Cancer Patients: A Randomized Phase III Trial

Recruiting now · Phase 3

Conditions studied: Cervical Cancer, Neoadjuvant Chemotherapy, Bulky Neoplasm

In brief

Evaluate the efficacy and safety of neoadjuvant chemotherapy (NAC) with albumin-bound paclitaxel and carboplatin followed by chemoradiation therapy (CRT) for stage IIIC cervical cancer patients with carcinoma \>4 cm in greatest dimension and/or lymph node \>2cm in short axis.

Key facts

Study ID

NCT05367206

Run by

Sun Yat-sen University

People needed

280

Starts

2022-03-14

Expected to finish

2027-03-31

Last updated by the study team

2022-05-10

Who can join

Age: 18 and older, up to 70. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• pathologically comfirmed : squamous cell, adenocarcinoma, or adenosquamous carcinoma of the uterine cervix；
• FIGO (2018 International Federation of Gynecology and Obstetrics) stage IIIC with carcinoma >4 cm in greatest dimension and/or lymph node >2 cm in short axis at initial diagnosis.
• age 18 to 70 years；
• Eastern Cooperative Oncology Group performance status 0 to 2；
• adequate organ function.

You may not qualify if…

• not at initial diagnosis; 2. with other kind of tumor.

Where it is running

• Sun Yat-sen University Cancer Center — Guangzhou, Guangdone, China (enrolling)

Full record on ClinicalTrials.gov

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