cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
Recruiting now
Conditions studied: Brain Cancer, Breast Cancer, Bladder Cancer, Cervical Cancer, Colorectal Cancer, Endometrial Cancer, Esophageal Cancer, Stomach Cancer, Head and Neck Cancer, Hepatobiliary Cancer, Leukemia, Lung Cancer, Lymphoma, Multiple Myeloma, Ovarian Cancer, Pancreatic Cancer, Prostate Cancer, Renal Cancer, Sarcoma, Thyroid Cancer
In brief
This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types. The cancers included in this study are brain, breast, bladder, cervical, colorectal, endometrial, esophageal, gastric, head and neck, hepatobiliary, leukemia, lung, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, renal, sarcoma, and thyroid. These cancers were selected based on their prevalence and mortality to maximize impact on clinical care. Additionally, the ability of the whole-genome methylome enrichment platform to detect minimal residual disease after completion of cancer treatment and to detect relapse prior to clinical presentation will be evaluated in lung cancer. This cancer was selected based on the existing clinical landscape and treatment availability.
Key facts
- Study ID
- NCT05366881
- Run by
- Adela, Inc
- People needed
- 7000
- Starts
- 2022-05-03
- Expected to finish
- 2027-03-01
- Last updated by the study team
- 2026-01-20
Who can join
Age: 40 and older. Sex: any. Healthy volunteers: accepted.
Where it is running
- Elligo Health Research, Inc. — Austin, Texas, United States (enrolling)
- Miami Cancer Institute — Miami, Florida, United States (enrolling)
- North Georgia Health System — Gainesville, Georgia, United States (enrolling)
- Baptist Floyd — New Albany, Indiana, United States (enrolling)
- Baptist Corbin — Corbin, Kentucky, United States (enrolling)
- Baptist Hardin — Elizabethtown, Kentucky, United States (enrolling)
- Baptist Lexington — Lexington, Kentucky, United States (enrolling)
- City of Hope — Duarte, California, United States (enrolling)
- Allina Health Cancer Institute — Minneapolis, Minnesota, United States (enrolling)
- Mayo Clinic — Rochester, Minnesota, United States (enrolling)
- Cleveland Clinic — Cleveland, Ohio, United States (enrolling)
- Oregon Health Sciences University — Portland, Oregon, United States (enrolling)
- Medical University of South Carolina — Charleston, South Carolina, United States (enrolling)
- McLeod Health — Florence, South Carolina, United States (enrolling)
- Baptist (BHMCC) — Memphis, Tennessee, United States (enrolling)
- Vanderbilt-Ingram Cancer Center — Nashville, Tennessee, United States (enrolling)
- Baptist Paducah — Paducah, Kentucky, United States
Full record on ClinicalTrials.gov
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