PV Loop & Coarctation Study

Running, not enrolling

Conditions studied: Coarctation of Aorta

In brief

Coarctation of the aorta accounts for 4-7% of all congenital heart disease. While stent therapy, when feasible, is the standard of care for coarctation, it may not completely improve the work (and afterload) of the heart due to its effects on the elasticity of the aorta. This study will provide the information needed to understand the effects of current management on the cardiac mechanics and work.

Key facts

Study ID

NCT05362721

Run by

University of Minnesota

People needed

21

Starts

2019-06-04

Expected to finish

2026-12-31

Last updated by the study team

2026-04-08

Who can join

Age: 6 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children 6 years of age and older and adults of all races and both sexes referred for elective cardiac catheterization and stent therapy for coarctation
• Those who provide informed consent for study participant.

You may not qualify if…

• Children who undergo other interventions in addition to the coarctation
• Children with single ventricle physiology.
• Renal impairment
• Participant unwilling to sign a consent form.

Where it is running

• Children's Hospital of Los Angeles — Los Angeles, California, United States
• Children's Hospital of Boston — Boston, Massachusetts, United States
• Helen DeVos Children's Hospital — Grand Rapids, Michigan, United States
• University of Minnesota — Minneapolis, Minnesota, United States
• Children's Mercy Hospital — Kansas City, Missouri, United States
• Cincinnati Children's Hospital — Cincinnati, Ohio, United States
• University of Texas-Southwestern — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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