Head-to-Head Harmonization of Tau Tracers in Alzheimer's Disease

Running, not enrolling · Phase 1

Conditions studied: Alzheimer Disease

In brief

The purpose of this study is to compare/harmonize cross-sectional and longitudinal tau tangle measurements obtained with the tau PET radiopharmaceuticals Flortaucipir and MK-6240 to elucidate the advantages and caveats of their use in clinical trials/practice and provide parameters to integrate their estimates.

Key facts

Study ID

NCT05361382

Run by

Tharick Pascoal

People needed

822

Starts

2022-03-02

Expected to finish

2027-05-31

Last updated by the study team

2025-10-29

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Have a study partner who will be able to provide an independent evaluation of functioning.
• Willing and capable of undergoing repeated MR/PET imaging.
• Fluent in a language approved by the coordinating center.
• At screening, must have no cognitive impairment, or meet criteria for single- or multiple-domain amnestic mild cognitive impairment or Alzheimer's disease dementia.

You may not qualify if…

• Inability to provide informed consent by self or by proxy.
• Pregnant or breastfeeding women.
• Have any condition or are taking any medication that could increase the risk to the participant, limit the ability to tolerate or interfere with the results of the tests and procedures (in the opinion of the investigator).

Where it is running

• Lawrence Berkeley National Laboratory — Berkeley, California, United States
• University of California San Francisco — San Francisco, California, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Washington University in St. Louis — St Louis, Missouri, United States
• University of Pittsburgh — Pittsburgh, Pennsylvania, United States
• Brown University — Providence, Rhode Island, United States
• Houston Methodist Neurological Institute — Houston, Texas, United States
• McGill University — Montreal, Quebec, Canada
• Sant Pau Biomedical Research Institute — Barcelona, Spain, Spain

Full record on ClinicalTrials.gov

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