Trial of Atezolizumab and Bevacizumab With SRF388 or Placebo in Patients With Hepatocellular Carcinoma
Completed · Phase 2 · Has a placebo group
Conditions studied: Hepatocellular Carcinoma
In brief
This is a Phase 2 trial composed of an open label Lead-In followed by a Randomized Phase designed to evaluate the efficacy and safety of SRF388 in combination with atezolizumab plus bevacizumab compared to placebo (inactive substance) in combination with atezolizumab plus bevacizumab in patients with first-line advanced or metastatic HCC.
Key facts
- Study ID
- NCT05359861
- Run by
- Coherus Oncology, Inc.
- People needed
- 30
- Starts
- 2022-04-12
- Expected to finish
- 2025-07-08
- Last updated by the study team
- 2026-06-29
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Arizona Cancer Center - North Campus — Tucson, Arizona, United States
- City of Hope — Duarte, California, United States
- University of Southern California - Norris Comprehensive Cancer Center — Los Angeles, California, United States
- University of Florida Health Science Center - Gainesville — Gainesville, Florida, United States
- University of Miami, Sylvester Comprehensive Cancer Center — Miami, Florida, United States
- Louisville VA Medical Center - Robley Rex VA Medical Center — Louisville, Kentucky, United States
- Veterans Affairs Ann Arbor Healthcare System — Ann Arbor, Michigan, United States
- University of Michigan Health System (UMHS) — Ann Arbor, Michigan, United States
- Henry Ford Hospital — Detroit, Michigan, United States
- Veterans Affairs New York Harbor Healthcare System - Manhattan VA Medical Center — New York, New York, United States
- NYU Langone Medical Center - Laura and Isaac Perlmutter Cancer Center (NYU Cancer Institute (NYUCI)) — New York, New York, United States
- University of Oklahoma Health Sciences Center - Stephenson Cancer Center — Oklahoma City, Oklahoma, United States
- Providence Portland Medical Center — Portland, Oregon, United States
- Sarah Cannon Research Institute - Tennessee Oncology — Chattanooga, Tennessee, United States
- Sarah Cannon Research Institute - Tennessee Oncology — Nashville, Tennessee, United States
- St George Hospital -Kogarah — Kogarah, Australia
- The Alfred Hospital — Melbourne, Australia
- Royal Melbourne Hospital — Melbourne, Australia
- Gold Coast Private Hospital — Southport, Australia
- The Catholic University of Korea - St. Vincent's Hospital — Suwon, Gyeonggi-do, South Korea
- Daegu Catholic University Medical Center (DCUMC) — Daegu, South Korea
- Chonnam National University (CNU) - Chonnam National University Hwasun Hospital (CNUHH) — Gwangju, South Korea
- Ajou University Hospital — Gyeonggi-do, South Korea
- CHA University - Bundang CHA General Hospital (CHA Bundang Medical Center) — Gyeonggi-do, South Korea
- Seoul National University Bundang Hospital — Seongnam, South Korea
Full record on ClinicalTrials.gov
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