A Study to Evaluate the Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD)
Completed · Phase 2 · Has a placebo group
Conditions studied: Huntington Disease
In brief
The primary goal of this study is to evaluate the safety and pharmacodynamic effects of PTC518 compared with placebo in participants with HD.
Key facts
- Study ID
- NCT05358717
- Run by
- Novartis Pharmaceuticals
- People needed
- 159
- Starts
- 2022-06-03
- Expected to finish
- 2025-07-31
- Last updated by the study team
- 2026-06-16
Who can join
Age: 25 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of California, San Diego — La Jolla, California, United States
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
- The University of Texas Health Science Center at Houston; McGovern Medical School — Houston, Texas, United States
- University of Washington Department of Neurology — Seattle, Washington, United States
- Monash Health — Clayton, Australia
- Westmead Hospital — Sydney, Australia
- Medical University Innsbruck — Innsbruck, Austria
- The Ottawa Hospital, Parkinson's and Movement Disorders Clinic — Ottawa, Canada
- Centre Hospitalier Universitaire d'Angers — Angers, France
- Hôpital Universitaire de Marseille Hôpital de la Timone — Marseille, France
- Brain and Spine Institute Paris — Paris, France
- Charite University Medicine Berlin — Berlin, Germany
- Ruhr-Univ. Bochum St. Joseph-Hospital — Bochum, Germany
- George-Huntington-Institut — Münster, Germany
- Ulm University, UKU, Dep. of Neurology — Ulm, Germany
- Irccs Istituto Delle Scienze Neurologiche Di Bologna Uoc Clinica Neurologica — Bologna, Italy
- IRCCS Carlo Besta Neurological Institutte — Milan, Italy
- IRCCS Casa Sollievo della Sofferenza Research Hospital — San Giovanni Rotondo, Italy
- Leiden University Medical Center — Leiden, Netherlands
- University of Otago, New Zealand Brain Research Institute — Christchurch, New Zealand
- Hospital Universitario Cruces — Barakaldo, Spain
- Hospital de la Santa Creu I Sant Pau — Barcelona, Spain
- Hospital Universitario Burgos — Burgos, Spain
- Hospital Ramón y Cajal — Madrid, Spain
- The Barbery National Centre for Mental Health — Birmingham, United Kingdom
Full record on ClinicalTrials.gov
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