Characterization of the Serotonin 2A Receptor Selective PET Tracer [18F]MH.MZ in Patients With Neurodegenerative Diseases
Recruiting now · Phase 4
Conditions studied: Neurodegenerative Diseases, Parkinson Disease, Parkinson Disease Psychosis
In brief
It is hypothesize that patients with clinically diagnosed neurodegenerative diseases will have significantly different receptor occupancy of 5HT2A receptors compared to a healthy age/sex-matched control group. This will be tested by measuring 5HT2A receptor density using the PET radioligand (R)-\[18F\]MH.MZ in both populations.
Key facts
- Study ID
- NCT05357612
- Run by
- Vanderbilt University Medical Center
- People needed
- 75
- Starts
- 2023-01-23
- Expected to finish
- 2027-08-01
- Last updated by the study team
- 2026-08-07
Who can join
Age: 50 and older, up to 85. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Patient arm - clinical diagnosis of Parkinson disease, diffuse Lewy body disease, multiple systems atrophy, Huntington's Disease, Frontotemporal Dementia, and other variants
- Healthy arm - age and gender matched to patient arm
- Psychosis (presence of hallucinations or delusions) starting after the diagnosis of Parkinson's disease, occurring at least weekly for 4 weeks, severe enough to warrant treatment.
- Study partner available for study visits
You may not qualify if…
- Prior stroke or other uncontrolled serious neurological or medical illness
- Contra-indication or inability to tolerate MRI scan
- Use of serotonergic medications in the last 6 weeks
- Incapable of providing independent consent.
- Pregnant or breastfeeding women
- psychosis due to a metabolic, toxic, or primary psychiatric disease
- Deemed unable to complete neurocognitive testing
- For PD Participants: current or prior use of pimavanserin
- Use of antipsychotics in the last 2 weeks
Where it is running
- Vanderbilt University Medical Center — Nashville, Tennessee, United States (enrolling)
Full record on ClinicalTrials.gov
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