Growth Hormone Replacement in Veterans With GWI and AGHD (GWIT)

Recruiting now · Phase 2

Conditions studied: Gulf War Syndrome, Adult Growth Hormone Deficiency

In brief

The goal of the GWIT Study is to assess whether growth hormone replacement therapy is a safe and effective treatment for veterans with Gulf War Illness (GWI) and adult growth hormone deficiency (AGHD). The main questions the study aims to answer are: 1. Is growth hormone effective at reducing fat in the trunk of the body and symptoms of GWI among veterans with GWI and growth hormone deficiency? 2. Do the results of the study suggest there is merit in pursuing a larger trial to examine the efficacy of growth hormone as a treatment for growth hormone deficiency among veterans with Gulf War Illness? To determine eligibility for the study, veterans will be asked to complete several assessments including questionnaires, blood tests, and a scan of the brain. Participants who qualify for the study will receive recombinant human growth hormone for 6-months. A body composition scan will be performed at Day1, Day 90, and Day 180 of the intervention. Questionnaires and cognitive tests will also be collected before and after the trial.

Key facts

Study ID: NCT05355272
Run by: Baylor College of Medicine
People needed: 20
Starts: 2024-03-11
Expected to finish: 2027-07-01
Last updated by the study team: 2026-05-08

Who can join

Age: 18 and older, up to 64. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

veteran of the Gulf War conflict with a history of deployment to Operation Desert Storm or Desert Shield between 1990-91
age less than or equal to 64 years old
have a diagnosis of Gulf War Illness assessed by study investigators
have adult growth hormone deficiency diagnosed by glucagon stimulation test (cut point 3.0 mcg/L if BMI is less than or equal to 25 or 1.0 mcg/L if BMI is greater than 25)
4-week stability on any psychotropic medications
3-month stability on all hormone treatments
able and willing to provide informed consent to participant in the study and complete study protocol

You may not qualify if…

history of a psychiatric disorder with substantial impact on functional status or quality of life (e.g., schizophrenia, schizoaffective disorder, bipolar, or other psychotic disorder)
history of neurologic disorder other than traumatic brain injury with substantial impact on the quality of life
other known cause for growth hormone deficiency (GHD) including history of childhood onset GHD, hypothalamic/pituitary disease, history of brain radiation, or genetic mutations known to lead to GHD
active suicidal ideation as determined by a score of 2 points or higher on the Columbia Suicide Severity Rating Scale
suicidal behavior in the past 6 months
contraindication to recombinant human growth hormone (rhGH) such as hypersensitivity to rhGH or any of the components of the supplied product
acute medical illness, active infection, cancer, or decompensated chronic medical illness (e.g., decompensated diabetes mellitus, congestive heart failure, chronic obstructive pulmonary disease)
evidence of substance use disorder in the past 6 months other than mild alcohol or cannabis use disorder diagnosed by clinician at time of screening.
urine toxicology evidence of illicit drug use (excluding cannabis) within the past 90 days prior to screening
BMI > 35 or body weight > 350 lbs
abnormal pituitary anatomy documented by an MRI using a Sella protocol
women who are pregnant or of child-bearing potential who are unable/unwilling to use one of the following barrier contraceptives: condoms, diaphragm, cervical cap, or intrauterine device
current use of the following: growth hormone, estrogen or estrogen-like dietary supplements, hormonal contraceptives, progestin, insulin growth factor 1 (IGF-1), or chronic glucocorticoid use in supraphysiologic doses
currently enrolled in any other interventional drug trials unless prior approval is provided by the study chairs and the study sponsor

Where it is running

Michael E. DeBakey VA Medical Center — Houston, Texas, United States (enrolling)
VA Puget Sound Healthcare System — Seattle, Washington, United States (enrolling)

Full record on ClinicalTrials.gov

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