HYDROcortisone Versus Placebo for Severe HospItal-acquired Pneumonia in Intensive Care Patients: the HYDRO-SHIP Study
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Healthcare-Associated Pneumonia, Ventilator Associated Pneumonia
In brief
The use of corticosteroids in patients with severe community pneumonia, bacterial infection which kills lots of patients around the world, reduces the mortality of this infection. However, there are no studies with this type of drug regarding hospital-acquired pneumonia. This is the first multicenter randomized trial to test hydrocortisone plus standard therapy in critical care patients with nosocomial pneumonia. This intervention is inexpensive and may improve the outcome of those patients, besides having an acceptable side effects profile.
Key facts
- Study ID
- NCT05354778
- Run by
- Instituto de Assistencia Medica ao Servidor Publico Estadual, Sao Paulo
- People needed
- 180
- Starts
- 2022-10-16
- Expected to finish
- 2027-02-01
- Last updated by the study team
- 2025-11-25
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18 years of age or older
- Suspected ou confirmed case of bacterial nosocomial pneumonia (including ventilator-associated pneumonia)
- Intensive Care Unit stay
- Signed consent form (by the patient or a legal guardian)
You may not qualify if…
- Women who are pregnant, have recently given birth or are breastfeeding
- Patients who are moribund or do not have a treatment perspective
- Patients with community acquired pneumonia
- Patients with other types of pneumonia (viral - including COVID-19, fungal etc.)
- Those with pulmonary infiltrates in chest image which are not compatible with bacterial pneumonia
- Patients with adrenal insufficiency
- Patients who have a condition that demands the use of corticosteroids (acute or chronic)
- Patients allergic to hydrocortisone
- Patients with refractory septic shock (those receiving more than 0,5mcg/kg/min of norepinephrine)
Where it is running
- Hospital do Servidor Publico Estadual — São Paulo, Sao Paulo SP, Brazil (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.