Exploration of Adaptive Antitumoral Immune Cells Through Lymphapheresis in Cancer Patients : ALCYTA

Recruiting now · Not applicable

Conditions studied: Cancer, Immune System or Toxicities Suspected

In brief

The study will evaluate the detection of tumor-antigen specific immune cells in cancer patients in whom the role of the immune system is suspected.

Key facts

Study ID

NCT05354765

Run by

Institut Curie

People needed

300

Starts

2022-08-31

Expected to finish

2027-09-03

Last updated by the study team

2026-05-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient aged 18 or over,
• Patient presenting an invasive tumor pathology (proven or suspected). The location and / or stage of which are defined for each cohort through an amendment to the protocol,
• Patient treated with immune-modulators or other treatments likely to modify immunological parameters,
• Suspicion of immune mediated response or toxicities (assessed by the immunologists),
• Peripheral venous capital usable and compatible with the realization of 2 venous accesses for lymphapheresis and absence of cardiovascular problem (heart failure, arrhythmia ...), per investigator assessement,
• Total circulating lymphocytes> 1000 / mm3,
• Availability of DNA and RNA from the tumor,
• Information to the patient and signature of informed consent or his legal representative,
• Affiliated with a social security scheme or such a scheme.

You may not qualify if…

• Inability to undergo study follow-up for geographical, social or psychological reasons,
• Infection with HIV or hepatitis B or C viruses,
• Patients on high dose corticosteroid treatment (> 1 mg / kg continuously),
• Any concomitant serious illness that may interfere with participation in the study or significantly affect the results of the study (pulmonary, heart or liver disease),
• Contraindication to performing lymphapheresis (coagulation disorder, cardiovascular problems, venous access, hypocalcemia, psychological inability to undergo extracorporeal circulation, cachexia, etc.),
• Pregnant patient or of childbearing age without effective contraception,
• Persons deprived of their liberty, under guardianship or legal protection.

Where it is running

• Institut Curie — Paris, France (enrolling)
• Institut Curie — Saint-Cloud, France (enrolling)

Full record on ClinicalTrials.gov

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