Pregistry International Pregnancy Exposure Registry (PIPER)

Stopped early

Conditions studied: Pregnancy Related

In brief

The aims of the Pregistry International Pregnancy Exposure Registry (PIPER) are to provide early signals of risk after prenatal exposure to medical products and to define boundaries of safety for medical products. The goal is to assist prescribers and study participants in weighing the potential risks of prenatal treatments on the wellbeing of mother and the unborn offspring. Specifically, the PIPER will estimate the risk of obstetric outcomes (spontaneous abortion, antenatal bleeding, gestational diabetes, gestational hypertension, intrauterine growth restriction, postpartum hemorrhage, fetal distress, uterine rupture, placenta previa, chorioamnionitis, Caesarean delivery, COVID-19), neonatal outcomes (major congenital malformations, low birth weight, neonatal death, neonatal encephalopathy, neonatal infections, neonatal acute kidney injury, preterm birth, respiratory distress in the newborn, small for gestational age, stillbirth, COVID-19), and infant outcomes (developmental milestones \[motor, cognitive, language, social-emotional, and mental health skills\], height, weight, failure to thrive, medical conditions during the first 12 months of life, COVID-19) among pregnant women.

Key facts

Study ID: NCT05352256
Run by: Pregistry
People needed: 300
Starts: 2022-10-01
Expected to finish: 2025-07-28
Last updated by the study team: 2025-07-31

Who can join

Age: 18 and older, up to 50. Sex: female. Healthy volunteers: accepted.

You may qualify if…

Pregnant at time of enrollment
Age ≥18 years at time of enrollment
Signed the informed consent form and submitted the baseline module
Resident of a country where a Central Institutional Review Board (IRB) or Ethics Committee provided approval to conduct the study or clearance that approval is not required to conduct the study

You may not qualify if…

Not pregnant at time of enrollment
Age <18 years at time of enrollment

Where it is running

Pregistry — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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