THERMotherapy Against Persistent Bacterial LUNG Infections

Starting soon · Not applicable

Conditions studied: Lung Diseases, Obstructive, Bronchiectasis, Asthma, Copd, Chronic Obstructive Pulmonary Disease, Chronic Lung Infections

In brief

The aim of this study is to determine whether an intervention with frequent thermotherapy will be able to reduce the amount of colonizing bacteria in the bronchoalveolar lavage sample and eradicate the colonizing bacteria.

Key facts

Study ID: NCT05351242
Run by: Chronic Obstructive Pulmonary Disease Trial Network, Denmark
People needed: 150
Starts: 2026-10-01
Expected to finish: 2029-12-31
Last updated by the study team: 2026-06-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Age ≥ 18 years
Competent and capable
FEV1>1,0 L
Have had a positive culture from sputum or BAL min. 2 times in the last 24 months for bacteria of the species: Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Staphylococcus aureus, Haemophilus influenzae, Achromobacter xylosoxidans, Klebsiella oxytoca or Klebsiella pneumoniae. In addition, min. 1 positive culture after treatment with antibiotics
Willing to go to a sauna (min. temperature of 85℃ for at least 7 minutes) four times weekly for six months or avoid going to a sauna for six months

You may not qualify if…

Allergy to lidocaine and/or midazolam
Contraindications to bronchoscopy
Previous severe laryngospasm (intubation requiring)
Pregnancy/breastfeeding
Severe linguistic problems or inability to give informed consent
Severe mental illness that is not controlled with medication. NB: Patients with controlled mental illness can be included and will be asked on an equal footing as others

Where it is running

Herlev and Gentofte University hospital — Hellerup, Capital Region, Denmark

Full record on ClinicalTrials.gov

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