Yogurt Supplementation to Alter Bone Biomarkers, the Gut Microbiota and Inflammation in Older Adults
Stopped early · Not applicable
Conditions studied: Osteoporosis, Inflammation
In brief
Caribbean Latino adults are a vulnerable population at risk for developing osteoporosis. In addition to lifestyle factors, such as dietary intake, the investigators hypothesize that a unhealthy gut microbial environment coupled with high inflammation contributes to the risk of developing osteoporosis. There has been little research conducted on mechanisms underpinning how a low-intensity dietary intervention, including supplementation with daily yogurt, can affect the gut health of Caribbean Latino adults. The study objectives are to: 1) determine whether daily yogurt supplementation reduces bone turnover (biomarkers of overall bone health) and inflammation compared to a control group that maintains their usual diet (void of yogurt); and 2) collect preliminary data on the effects of daily yogurt supplementation on the gut microbiome compared to diet control group.
Key facts
- Study ID
- NCT05350579
- Run by
- University of Massachusetts, Lowell
- People needed
- 33
- Starts
- 2019-03-28
- Expected to finish
- 2020-03-25
- Last updated by the study team
- 2022-04-28
Who can join
Age: 50 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- self-reported Caribbean Latino descent
- at least 50 years of age
You may not qualify if…
- usual yogurt intake (> 2 servings per week)
- use of antibiotics in the past 6 months
- regular weekly laxative use
- self-reported osteoporosis
- history of osteoporosis-related fracture
- self-reported diagnosis of cancer
- self-reported diagnosis of gastrointestinal diseases (Crohn's disease, ulcerative colitis, Clostridium difficile infection)
- history of gastrointestinal alteration procedures (appendectomy, gastric bypass surgery)
- use of osteoporosis drugs
- use of steroids
- use of chemotherapeutic agents
Where it is running
- Lawrence Senior Center — Lawrence, Massachusetts, United States
Full record on ClinicalTrials.gov
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