Monocyte Priming When Consuming a Western Diet

Completed · Not applicable

Conditions studied: Heart Diseases

In brief

To determine the mechanism of monocyte priming in humans, the study team will conduct a complete feeding trial in normal weight and metabolically healthy human subjects (20-45 years of age) using a western diet (WD), characterized as being high-saturated fat, high-fructose, and high-calorie for 8 weeks.

Key facts

Study ID

NCT05348395

Run by

Wake Forest University Health Sciences

People needed

8

Starts

2023-01-06

Expected to finish

2024-10-11

Last updated by the study team

2026-03-06

Who can join

Age: 20 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 20-45
• Planning to be available for the entire study period
• Able to speak and read English
• Normal weight (body mass index 18.5-24.9 kg/m2)
• Able to eat the prescribed diet
• Non-smoker

You may not qualify if…

• Excessive alcohol consumption
• History of chronic cardiometabolic disease or major risk factor, including diabetes, hypertension, hyperlipidemia, heart disease
• History of prior surgical procedure for weight control or liposuction
• Use of weight loss medications in previous 6 months
• Recent self-reported weight change
• Severe pulmonary disease requiring supplemental oxygen
• Abnormal renal or liver function
• History of non-skin cancer in the past 5 years
• Regular use of medications (prescribed or over-the-counter) that affect blood pressure, lipids, glucose, inflammation, or body weight
• Works night shifts
• Exercise per week > 420 minutes total for moderate activity or > 210 minutes for vigorous activity
• Any medical or behavioral indication that would make participation unsafe based on the judgement of the study physician
• Pregnant or lactating women
• Known or discovered intolerances, allergies or difficulty consuming any of the foods included in the study diets

Where it is running

• Wake Forest University Health Sciences — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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