Nirogacestat in Ovarian Granulosa Cell Tumors
Completed · Phase 2
Conditions studied: Ovarian Granulosa-Stromal Tumor, Ovarian Granulosa Cell Tumor, Ovarian Cancer
In brief
This phase 2 clinical trial will study the effectiveness of nirogacestat in ovarian granulosa cell tumors (OvGCTs). Nirogacestat is a gamma secretase inhibitor (GSI) which is hypothesized to decrease the growth and activity of ovarian granulosa tumors.
Key facts
- Study ID
- NCT05348356
- Run by
- SpringWorks Therapeutics, Inc.
- People needed
- 53
- Starts
- 2022-08-30
- Expected to finish
- 2025-07-14
- Last updated by the study team
- 2025-12-15
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
Where it is running
- USC/Norris Comprehensive Cancer Center — Los Angeles, California, United States
- UCLA-JCCC Dept. of OBGYN - Women's Health Clinical Research Unit — Los Angeles, California, United States
- AdventHealth Orlando — Orlando, Florida, United States
- Orlando Health Cancer Institute — Orlando, Florida, United States
- H. Lee Moffitt Cancer Center and Research Institute — Tampa, Florida, United States
- Women's Cancer Care — Covington, Louisiana, United States
- Greater Baltimore Medical Center — Baltimore, Maryland, United States
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States
- David C. Pratt Cancer Center — St Louis, Missouri, United States
- University of New Mexico Comprehensive Cancer Center — Albuquerque, New Mexico, United States
- Columbia University Medical Center — New York, New York, United States
- Memorial Sloan Kettering Cancer Institute — New York, New York, United States
- Women's Cancer Center at Kettering — Kettering, Ohio, United States
- OU Health Stephenson Cancer Center — Oklahoma City, Oklahoma, United States
- UW/Fred Hutch Cancer Center — Seattle, Washington, United States
- Froedtert and Medical College of Wisconsin — Milwaukee, Wisconsin, United States
- Cross Cancer Institute — Edmonton, Alberta, Canada
- Maria Sklodowska-Curie Bialystok Oncology Center — Bialystok, Poland
- Jagiellonian Innovation Centre Clinical Research Centre — Krakow, Poland
- University Teaching Hospital Poznan, Department of Oncological Gynaecology — Poznan, Poland
- Maria Sklodowska-Curie National Institute of Oncology-National Research Institute, Clinic of Oncological Gynecology — Warsaw, Poland
Full record on ClinicalTrials.gov
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