Optimizing Pulsatility During Cardiopulmonary Bypass

Recruiting now

Conditions studied: Endothelial Dysfunction, Acute Kidney Injury

In brief

Cardiopulmonary bypass during cardiac surgery provides blood flow to the body during surgery but has adverse effects on different organs. Blood flow during cardiopulmonary bypass may be pulsatile or non-pulsatile, which may impact normal organ function after surgery. The study will collect data on the type of cardiopulmonary bypass used during surgery and organ function to determine if there is an association between the type of bypass and organ function.

Key facts

Study ID

NCT05344573

Run by

University of Colorado, Denver

People needed

66

Starts

2022-07-05

Expected to finish

2025-07-01

Last updated by the study team

2024-11-21

Who can join

Age: 50 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 50 to 70
• Able to provide informed consent
• Scheduled for elective cardiac surgery with cardiopulmonary bypass

You may not qualify if…

• Patients undergoing emergency procedures
• Diagnosed with sepsis
• Experiencing delirium
• Experiencing hemodynamic instability (heart rate > 100 and systolic blood pressure < 90)
• Patients with a mechanical circulatory support device
• Requiring vasoactive medications before surgery
• Patients with a reduced left ventricular ejection fraction (less than 50%)
• Patients with a contraindication to transesophageal echocardiography

Where it is running

• University of Colorado Hospital — Aurora, Colorado, United States (enrolling)

Full record on ClinicalTrials.gov

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