The Effect of Laparoscopic Splenectomy and Azygoportal Disconnection on the Immune Function for Cirrhosis Patients

Recruiting now · Not applicable

Conditions studied: Cirrhosis, Liver, Splenectomy; Status

In brief

In this study, the investigators compared the improvement of immune function related indicators in patients with liver cirrhosis after laparoscopic splenectomy and azygoportal disconnection. To determine whether surgical treatment can help enhance postoperative immune function and improve patient prognosis.

Key facts

Study ID

NCT05338294

Run by

Northern Jiangsu People's Hospital

People needed

20

Starts

2022-03-01

Expected to finish

2025-07-31

Last updated by the study team

2025-05-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• A clinical, radiological or histologic diagnosis of cirrhosis of any etiology
• Splenomegaly with secondary hypersplenism
• gastroesophageal variceal bleeding
• Informed consent to participate in the study

You may not qualify if…

• Hepatocellular carcinoma or any other malignancy,
• Child-Pugh grade C
• Recent peptic ulcer disease
• History of Hemorrhagic stroke
• Pregnancy.
• Uncontrolled Hypertension
• Human immunodeficiency virus (HIV) infection

Where it is running

• Clinical Medical College, Yangzhou University — Yangzhou, Jiangsu, China (enrolling)

Full record on ClinicalTrials.gov

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