An Observational Study Evaluating Patients With Chronic Liver Diseases Associated With Hepatic Steatosis

Recruiting now

Conditions studied: Chronic Liver Disease

In brief

Hepatic steatosis may cause inflammation and fibrosis within the liver potentially leading to end-stage liver disease cirrhosis, liver failure and death. The condition is associated with several other chronic liver diseases like autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, hereditary hemochromatosis and alpha-1-antitrypsin deficiency and may also develop secondary to other diseases like inflammatory bowel disease and chronic pancreatitis. Diagnosing chronic liver diseases can be challenging and treatment may be limited. In-depth phenotyping at a tissue level may generate insight into the underlying pathophysiology of diseases and furthermore identify common as well as specific diagnostic biomarkers and future treatment targets of the diseases. We therefore undertake a study that evaluates patients with chronic liver diseases associated with hepatic steatosis.

Key facts

Study ID

NCT05335603

Run by

University of Copenhagen

People needed

335

Starts

2020-08-24

Expected to finish

2036-08-01

Last updated by the study team

2022-04-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adult patients/healthy control participants (age 18 or above) who can give their informed consent
• Suspected liver disease:
• non-alcoholic steatohepatitis
• alcoholic steatohepatitis
• autoimmune hepatitis
• primary biliary cholangitis
• primary sclerosing cholangitis
• inflammatory bowel disease
• polycystic ovary syndrome
• hereditary haemochromatosis
• chronic pancreatitis
• cystic fibrosis
• alpha-1 antitrypsin deficiency

You may not qualify if…

• Patients with:
• malignant diseases
• viral hepatitis
• human immunodeficiency virus
• contraindications to liver biopsy

Where it is running

• Hvidovre University Hospital — Hvidovre, Denmark (enrolling)

Full record on ClinicalTrials.gov

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