Optoacoustic Detection of Inflammation Using MSOT Device

Stopped early · Not applicable

Conditions studied: Graft Vs Host Disease, Colitis, Crohn Disease

In brief

The purpose of this study is to evaluate the safety and potential of a new experimental imaging instrument called multispectral optoacoustic tomography (MSOT) to detect inflammation in patients with chronic graft versus host disease of the skin or GI tract, Crohn's disease, or Colitis disease.

Key facts

Study ID: NCT05333978
Run by: University of Oklahoma
People needed: 29
Starts: 2022-05-31
Expected to finish: 2026-04-20
Last updated by the study team: 2026-06-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patients documented clinical/pathologic 1) acute or chronic colon or skin GVHD, 2) Crohn's disease, or 3) colitis
Have acceptable hematologic status [total hemoglobin (tHb) ≥ 7.0 mg/dL]
Patients ≥ 18 yrs of age
Willing to comply with study procedures and be available for the duration of the study
Patient has ability to understand and the willingness to provide a signed and dated IRB-approved informed consent document.

You may not qualify if…

Patients with a tattoo over the area of inflammation
Pregnant patients are not eligible for this trial. Eligible patients (if applicable) will be required to document the date of the first day of their last menstrual cycle, and provide a negative pregnancy test if sexually active and of childbearing potential
Patients who are breastfeeding
Any open wound (skin ulcerations or infections) at or near the site of imaging that would preclude MSOT imaging.
Any febrile illness that precludes or delays participation preoperatively

Where it is running

University of Oklahoma Health Sciences Center, Stephenson Cancer Center — Oklahoma City, Oklahoma, United States

Full record on ClinicalTrials.gov

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