Long-term Outcomes of Conservative Management in Patients with Moyamoya Disease and Their First-degree Relatives (LAMORA)

Recruiting now

Conditions studied: Moyamoya Disease

In brief

The purpose of this study is to investigate the long-term outcomes of conservative management in patients with moyamoya disease and their first-degree relatives, and provide potential pathogenesis of moyamoya disease.

Key facts

Study ID

NCT05332756

Run by

Beijing Tiantan Hospital

People needed

400

Starts

2022-05-01

Expected to finish

2026-12-31

Last updated by the study team

2024-12-19

Who can join

Age: 2 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with age between 2-60 years;
• A clinical diagnosis of moyamoya disease, including unilateral and bilateral disease.
• Patients are medically treated with antiplatelets, antiepileptics, antihypertensives and vasodilators depending on the presentation.
• Capable of understanding the purpose and risk of the study and has signed the informed consent. If the participant is not capable of this at the time of enrollment, a legally authorized representative will provide written informed consent in accordance with all regulations.
• Ability to comply with study follow-up.

You may not qualify if…

• Concomitant other diseases, including systemic vasculitis, neurofibroma, meningitis, sickle cell disease, down's syndrome, and previous basilar radiotherapy.
• Patients with cardiogenic embolism, including a history of atrial fibrillation, valvular disease or cardiac valve replacement.
• Patients are allergic to the contrast agents.
• Patients are treated with direct, indirect, or combined revascularization depending on the presentation.
• Physical or subjective failure to cooperate with the examination or serious comorbid diseases.
• Patients are unable or unlikely to return for follow-up visits.
• Any other reasons that, in the opinion of the investigators, make the participant unsuitable for enrollment.

Where it is running

• Beijing Tiantan Hospital Capital Medical University — Beijing, Beijing Municipality, China (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.