Effect of Attentional Therapy on Post-traumatic Stress Disorder
Recruiting now · Not applicable
Conditions studied: Post Traumatic Stress Disorder
In brief
Post-traumatic stress disorder (PTSD) is associated with an attentional bias towards negative stimuli, which is supposed to contribute to the development and the maintenance of the disorder. We recently showed using eye-tracking evidenced two types of AB towards negative stimuli: a "physiological AB" found both in healthy and individual with PTSD, characterized by a stronger initial attentional engagement towards negative stimuli compared to neutral stimuli, as revealed by longer first fixation duration dwell time on negative pictures than on neutral pictures; a "pathological bias" observed only in individuals with PTSD and characterized by an heightened sustained attention towards negative stimuli once detected, which further increases with prolonged exposure. The present study aimed at assessing the effectiveness of an eye-tracking assisted attentional bias reduction therapy, targeting specifically the pathological bias on the reduction of PTSD symptoms
Key facts
- Study ID
- NCT05331534
- Run by
- University Hospital, Lille
- People needed
- 140
- Starts
- 2024-02-02
- Expected to finish
- 2029-02-02
- Last updated by the study team
- 2025-08-24
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Understanding and able to express themselves in French
- Giving informed consent, by dating and signing the study participation form
- Having health insurance coverage
- Normal or corrected to normal vision and hearing
- DSM-5 PTSD criteria, assessed using the CAPS and PCL-5
You may not qualify if…
- Minors or adults under guardianship, under judicial protection, persons deprived of liberty
- Pregnant or breastfeeding women
- Refusal to participate after being clearly and fairly informed about the study
- Sensory, visual or auditory incapacity to participate in the study
- Personal history of neurological disorder or current neurological disorder
- Use of drugs other than tobacco and alcohol
- Alcohol use on the day of experimentation
- Personal history of psychiatric disorders or current psychiatric disorders other than anxiety, depressive, or trauma and stress disorders assessed at clinical interview and with MINI
- Personal history of multiple trauma in childhood
- Psychotropic medication treatment not stabilized over the past 4 weeks
- MOCA < 26
- Contraindication to prolonged exposure therapy
Where it is running
- Hôpital Fontan 2 — Lille, France (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.