Upifitamab Rilsodotin Maintenance in Platinum-Sensitive Recurrent Ovarian Cancer (UP-NEXT)

Stopped early · Phase 3 · Has a placebo group

Conditions studied: High Grade Serous Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer

In brief

UP-NEXT is a double-blind, randomized, placebo-controlled study of the antibody-drug conjugate (ADC) XMT-1536 (upifitamab rilsodotin) administered as an intravenous infusion once every four weeks in patients with recurrent, platinum-sensitive high-grade serous ovarian cancer (HGSOC), including fallopian tube and primary peritoneal cancer, expressing high levels of NaPi2b.

Key facts

Study ID

NCT05329545

Run by

Mersana Therapeutics

People needed

20

Starts

2022-06-23

Expected to finish

2023-09-29

Last updated by the study team

2023-10-26

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Participant must have a histological diagnosis of high grade serous ovarian cancer, which includes fallopian tube and primary peritoneal cancer, that is metastatic or recurrent.
• Participant must have platinum-sensitive recurrent disease, defined as having achieved either a partial or complete response to 4 or more cycles in their penultimate platinum- containing regimen and their disease progressing more than 6 months after completion of the last dose of platinum containing therapy in the penultimate regimen.
• Participant must have had 4 to 8 cycles of platinum-based chemotherapy in 2nd to 4th line setting in their most recent treatment regimen as defined below:
• Platinum-based chemotherapy regimens allowed immediately preceding enrollment to the study: carboplatin or cisplatin ±: paclitaxel, docetaxel, pegylated liposomal doxorubicin or gemcitabine.
• Participant must receive first study treatment infusion between 4 and 12 weeks after completing final dose of platinum in the most recent platinum-based regimen.
• Participant must have had as their best response to last line of treatment one of the following: No Evidence of Disease (NED); Complete Response (CR); Partial Response (PR); OR Stable Disease (SD)
• Participants with NED, CR, or PR as their best response to most recent line of treatment and who have not received treatment with a prior PARP inhibitor must have definitive BRCA1 and BRCA2 testing results that demonstrate no evidence of a deleterious BRCA1 or BRCA2 mutation. Somatic BRCA mutation testing is required for participants who are classified as not having a deleterious mutation by germline testing alone.
• Participant must provide either a tumor tissue block or fresh cut slides for measurement of NaPi2b expression by a central laboratory. If sufficient archival tumor tissue is not available, then a tumor tissue block or slides must be obtained from a fresh biopsy and provided to the central laboratory. Confirmation of a NaPi2b-H/positive tumor by the central laboratory is required prior to randomization.

You may not qualify if…

• Participant has received prior treatment with mirvetuximab soravtansine or another ADC containing an auristatin or maytansinoid payload.
• Participant has received bevacizumab in combination with last platinum-based regiment or plans to receive maintenance therapy outside the study intervention.
• Participant has clinical signs or symptoms of gastrointestinal obstruction and/or requirement for parenteral hydration or nutrition.
• Participant has ascites or pleural effusion managed with therapeutic paracentesis or thoracentesis within 28 days prior to signing the principal study consent form.
• Participant has history of cirrhosis, hepatic fibrosis, esophageal or gastric varices, or other clinically significant liver disease. Testing beyond laboratory studies otherwise defined in the eligibility criteria, to diagnose potentially clinically significant liver disease based on risk factors such as hepatic steatosis or history of excessive alcohol intake, will be based on clinical judgement of the investigator.
• Participant has history of or suspected pneumonitis or interstitial lung disease.
• Participant has untreated CNS metastases (including new and progressive brain metastases), history of leptomeningeal metastasis, or carcinomatous meningitis.

Where it is running

• HonorHealth Research Institute - HonorHealth VGPCC Biltmore — Phoenix, Arizona, United States
• The University of Arizona Cancer Center — Tucson, Arizona, United States
• University of California Los Angeles, Gynecologic Oncology Clinic — Los Angeles, California, United States
• University of California, Irvine Medical Center — Orange, California, United States
• Sarasota Memorial Hospital — Sarasota, Florida, United States
• University of Chicago Medical Center — Chicago, Illinois, United States
• WK Physicians — Shreveport, Louisiana, United States
• Karmanos Cancer Institute - Detroit — Detroit, Michigan, United States
• Billings Clinic — Billings, Montana, United States
• Methodist Hospital — Omaha, Nebraska, United States
• Women's Cancer Center of Nevada — Las Vegas, Nevada, United States
• Center of Hope — Reno, Nevada, United States
• University of New Mexico Cancer Center — Albuquerque, New Mexico, United States
• Southwest Women's Oncology — Albuquerque, New Mexico, United States
• University Hospitals Cleveland Medical Center, Seidman Cancer Center — Cleveland, Ohio, United States
• Kettering Health Cancer Center — Kettering, Ohio, United States
• Stephenson Cancer Center — Oklahoma City, Oklahoma, United States
• Willamette Valley Cancer Institute and Research Center — Eugene, Oregon, United States
• Legacy Good Samaritan Medical Center - Legacy Medical Group - Gynecologic Oncology — Portland, Oregon, United States
• Asplundh Cancer Pavilion — Willow Grove, Pennsylvania, United States
• Sanford Gynecologic Oncology — Sioux Falls, South Dakota, United States
• Avera McKennan d/b/a Avera Research Institute — Sioux Falls, South Dakota, United States
• Texas Oncology P.A. - Austin — Austin, Texas, United States
• Texas Oncology - DFWW — Bedford, Texas, United States
• Texas Oncology - Tyler — Tyler, Texas, United States

Full record on ClinicalTrials.gov

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