Non-invasive Neurostimulation as a Tool for Diagnostics and Management for Neurodegenerative Diseases

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Alzheimer Disease, Frontotemporal Dementia, Dementia With Lewy Bodies

In brief

Double blinded, sham-controlled, randomized trial on repeated transcranial alternating current brain stimulation (tACS) in neurodegenerative diseases. The investigators will evaluate whether a 4-times daily repeated stimulation with gamma tACS on the posterior parietal cortex can improve symptoms in patients with neurodegenerative diseases, including dementia with Lewy Bodies, Alzheimer's disease, idiopathic normal pressure hydrocephalus and Frontotemporal dementia.

Key facts

Study ID

NCT05326750

Run by

Kuopio University Hospital

People needed

200

Starts

2022-11-21

Expected to finish

2032-07-01

Last updated by the study team

2025-09-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Mild Cognitive Impairment due to Alzheimer's disease
• Dementia with Lewy Bodies
• Frontotemporal dementia
• Idiopathic normal pressure hydrocephalus (iNPH)

You may not qualify if…

• History of seizures
• Pregnancy
• Metal implants in the head (except dental fillings)
• Electronic implants (i.e. pace-maker, implanted medical pump)
• Age <18 years

Where it is running

• Kuopio University Hospital — Kuopio, Finland (enrolling)

Full record on ClinicalTrials.gov

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