Renal Biopsies in Post-liver Transplantation Patients With Renal Impairment

Recruiting now

Conditions studied: Liver Transplantation, Renal Insufficiency, Chronic

In brief

Investigators will conduct this single-center, prospective cohort study to explore the prevalence and risk factors of renal function progression in post-liver transplantation patients with renal impairment after renal biospy and to understand the the pathology of kidney disease in post-liver transplantation patients with renal impairment.

Key facts

Study ID: NCT05326399
Run by: RenJi Hospital
People needed: 369
Starts: 2022-06-01
Expected to finish: 2030-12-31
Last updated by the study team: 2025-11-28

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

age 18-75 years
patients received liver transplantation
new onset of proteinuria(defined as 24-hour proteinuria>1g/24h, or Urinary albumin creatinine ratio(UACR)>300mg/g on at least two occasions), and/or renal impairment: eGFR <60 mL/min/1.73 m² at least two occasions, and/or serum creatinine increase ≥50% from baseline
have received renal biopsy in the past 3 months
Signed informed consent form(ICF)

You may not qualify if…

patients received renal transplantation
hepatic failure
severe bleeding risk or platelet <70*109/L
chronic kidney insufficiency with eGFR<30ml/min·1.73m2,or kidney atrophy, or solitary kidney, or medullary sponge kidney, or polycystic kidney, or obstructive nephropathy
uncontrolled mental disease or unable to cooperate during operation
Pregnancy or lactation
not suitable for this study judged by investigaters

Where it is running

Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine — Shanghai, China (enrolling)
Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine — Shanghai, China

Full record on ClinicalTrials.gov

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