Clinical Registry of Long-Term Dental Outcomes in Head and Neck Cancer Patients

Completed

Conditions studied: Head and Neck Cancer, Dental Diseases, Osteoradionecrosis

In brief

The current study (ORARAD II) will examine participants of the original cohort for a visit roughly 7 years after the start of RT. The primary outcomes will be the 7-year rate of dental caries, periodontal disease, tooth loss, osteoradionecrosis and salivary flow.

Key facts

Study ID

NCT05325970

Run by

Wake Forest University Health Sciences

People needed

202

Starts

2014-02-01

Expected to finish

2026-02-04

Last updated by the study team

2026-06-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Enrolled in the original ORARAD study
• Willing to participate and comply with all study procedures

You may not qualify if…

• Anything that would place the participant at increased risk or preclude the participant's full compliance with or completion of the study (e.g., unable to obtain consent or unable to tolerate an oral examination).

Where it is running

• University of Connecticut Health Center - School of Dental Medicine — Farmington, Connecticut, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• University of Minnesota — Minneapolis, Minnesota, United States
• New York University - College of Dentistry — New York, New York, United States
• University of North Carolina School of Dentistry — Chapel Hill, North Carolina, United States
• University of Pennsylvania School of Dental Medicine — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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