Resting State Changes Following Theta Burst Stimulation

Recruiting now · Not applicable

Conditions studied: Brain Connectivity

In brief

Transcranial magnetic stimulation (TMS) is increasingly being applied to effectively treat mental illness, however efforts to quantify the effects of TMS on the network architecture of the brain have largely been limited in scope and tied to specific neurologic and psychiatric disorders. The objective of the current work is to build and validate a whole-brain, domain-general model of brain connectivity changes following TMS, based on physical models of the current distribution at the cortex. PUBLIC HEALTH RELEVANCE: This work is relevant to public health because it will provide direct evidence that brain connectivity changes following neuromodulatory TMS vary as a function of the current density at the cortex, which can be used to predict psychiatric symptom change following neuromodulatory TMS.

Key facts

Study ID

NCT05322239

Run by

Nicholas Balderston, PhD

People needed

200

Starts

2022-11-17

Expected to finish

2027-08-01

Last updated by the study team

2026-01-07

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Able to give their consent
• Right-handed

You may not qualify if…

• Non-english speaking
• Any significant medical problems
• Current or past Axis I psychiatric disorder(s),
• Active or history of active suicidal ideation
• Alcohol/drug problems in the past year or lifetime alcohol or drug dependence
• Medications that act on the central nervous system
• History of seizure
• History of epilepsy or other neurological problems
• Increased risk of seizure for any reason
• Pregnancy
• Any medical condition that increases risk for fMRI or TMS
• Any metal in their body which would make having an MRI scan unsafe
• Any sort of medical implants
• Claustrophobia

Where it is running

• University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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