Response of Cardiometabolic Biomarkers and Gut Microbiota to Walnut Consumption

Running, not enrolling · Not applicable

Conditions studied: Cardiovascular Diseases

In brief

The purpose of this research is to test if eating walnuts will cause any changes in blood lipids (like good and bad cholesterol, for example) and levels of inflammation in the blood, as well as changes in the bacteria living in the gut.

Key facts

Study ID

NCT05321277

Run by

University of California, Davis

People needed

30

Starts

2022-04-19

Expected to finish

2026-08-01

Last updated by the study team

2026-02-10

Who can join

Age: 45 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Overweight and obese men and postmenopausal women between 45-70 years of age, BMI range of 25.0-39.9 kg/m2 and elevated LDL-C levels (130-189 mg/dL).

You may not qualify if…

• Adults unable to consent, individuals who are not yet adults (infants, children, teenagers), pregnant or lactating women, women planning to become pregnant in the next four months and prisoners will be specifically excluded.
• Additional exclusion criteria are listed below:
• Allergy to walnuts or other nuts
• Eating more than 25 grams of fiber per day, assessed by the Block Dietary-Fruit-Vegetable-Fiber Screener©
• Taking medications or supplements known to affect metabolism or gut microbiota composition (i.e. Metformin, statins, antibiotics within the past 3 months, fiber supplements, probiotics, and others)
• Documented chronic diseases including diabetes, renal or liver disease, metabolic syndrome, active cancer, MI or stroke, history of gastric bypass or GI disease (e.g. Crohn's Disease, Irritable Bowel Disease, diverticulosis, diverticulitis, etc.)
• Smoker or living with a smoker, including vaporizer and/or electronic cigarettes.
• Illicit drug use, cannabis usage, or consuming >1 alcoholic drink/day
• Extreme dietary or exercise patterns
• Recent weight fluctuations (>10% in the last 6 months)
• Taking prescription lipid medications or supplements that may affect lipoprotein metabolism (i.e. >1 g of fish oil/day, antioxidant supplements)
• Taking exogenous hormones
• Poor venous access
• Unwillingness to comply with study protocols

Where it is running

• Ragle Human Nutrition Center — Davis, California, United States

Full record on ClinicalTrials.gov

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