Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia
Recruiting now · Phase 1/Phase 2
Conditions studied: Myelofibrosis; Anemia, Anemia, Myelofibrosis, Myelofibrosis Due to and Following Polycythemia Vera, Primary Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis, Myelodysplastic Syndromes
In brief
This phase 1b/2a open-label study will evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and clinical activity of DISC-0974 as well as categorize the effects on hematologic response in participants with myelofibrosis or myelodysplastic syndrome and anemia.
Key facts
- Study ID
- NCT05320198
- Run by
- Disc Medicine, Inc
- People needed
- 150
- Starts
- 2022-06-06
- Expected to finish
- 2027-06-01
- Last updated by the study team
- 2026-07-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Perth Blood Institute — West Perth, Australia (enrolling)
- City of Hope - Duarte — Duarte, California, United States (enrolling)
- City of Hope - Lennar — Irvine, California, United States (enrolling)
- University of California, San Francisco — San Francisco, California, United States (enrolling)
- University of Colorado Anschutz Medical Campus — Aurora, Colorado, United States (enrolling)
- Mayo Clinic Jacksonville — Jacksonville, Florida, United States (enrolling)
- Sylvester Cancer Center - U Miami — Miami, Florida, United States (enrolling)
- Moffitt Cancer Center — Tampa, Florida, United States (enrolling)
- Emory Winship Cancer Institute — Atlanta, Georgia, United States (enrolling)
- University of Michigan — Ann Arbor, Michigan, United States (enrolling)
- Mayo Clinic Rochester — Rochester, Minnesota, United States (enrolling)
- Washington University St.Louis — St Louis, Missouri, United States (enrolling)
- Memorial Sloan Kettering Cancer Center — New York, New York, United States (enrolling)
- Icahn School of Medicine at Mount Sinai — New York, New York, United States (enrolling)
- Montefiore — New York, New York, United States (enrolling)
- Atrium Health Wake Forest Baptist — Winston-Salem, North Carolina, United States (enrolling)
- St. Vincent's Hospital — Sydney, Australia (enrolling)
- Banner MD Anderson — Gilbert, Arizona, United States (enrolling)
- Cleveland Clinic — Cleveland, Ohio, United States (enrolling)
- The Ohio State University — Columbus, Ohio, United States (enrolling)
- Oregon Health and Science University — Portland, Oregon, United States (enrolling)
- University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)
- MD Anderson — Houston, Texas, United States (enrolling)
- University of Washington — Seattle, Washington, United States (enrolling)
- Medical College of Wisconsin — Milwaukee, Wisconsin, United States (enrolling)
Full record on ClinicalTrials.gov
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