TSH Suppression During Radiotherapy on Thyroid Site to Prevent Iatrogenic Hypothyroidism in Pediatric Cancer Patients

Recruiting now · Phase 3

Conditions studied: Hypothyroidism; Irradiation

In brief

To offer the possibility of a treatment that could achieve a meaningful reduction in the incidence of post-radiation therapy hypothyroidism. Thyroid dysfunction may develop from a few months to several years after patients have completed their radiation treatment. In children with chronic diseases, or given lengthy anti-neoplastic treatments, recurrent or persistent endocrine disorders may have a negative effect on growth and development into adulthood.

Key facts

Study ID

NCT05316922

Run by

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

People needed

68

Starts

2021-12-13

Expected to finish

2029-09-30

Last updated by the study team

2023-12-06

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Any patient with medulloblastoma, Hodgkin/non-Hodgkin Lymphoma before radiotherapy (RT) planning including thyroid parenchyma without previous primary or secondary hypothyroidism;
• Written informed consent prior to any study-specific analysis and/or data collection.

You may not qualify if…

• Any patient with medulloblastoma, Hodgkin/non-Hodgkin Lymphoma after radiotherapy including thyroid parenchyma;
• Not signed consent.

Where it is running

• Fondazione IRCCS Istituto Nazionale dei Tumori — Milan, Italy (enrolling)

Full record on ClinicalTrials.gov

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