Sitting Interruption and Whole-body Cardiovascular Health

Recruiting now · Not applicable

Conditions studied: Sedentary Behavior, Sedentary Time

In brief

There is strong evidence for the association between sedentary behaviors and cardiovascular diseases such as coronary heart disease and stroke. However, the public currently has no clear guidance on how to limit or interrupt their sedentary behaviors. This study will identify and test the physiological effects of several sedentary behavior interruption strategies and explore the feasibility (i.e., likelihood of an individual performing the requested activities) of those strategies to inform the development of public policy surrounding sedentary behavior interruption. Long-term, the findings of this study will inform a large clinical trial that can test whether sedentary behavior reduction can decrease cardiovascular disease risk.

Key facts

Study ID

NCT05316571

Run by

University of North Carolina, Chapel Hill

People needed

56

Starts

2022-08-15

Expected to finish

2026-05-31

Last updated by the study team

2026-03-16

Who can join

Age: 30 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Aged between 30-60 years
• Insufficiently active: self-reported exercise <90 minutes per week for the past 3 months
• Sedentary: self-reported sitting >8 hours per day
• Self-reported ability to walk 4 blocks and climb 2 flights of stairs
• Possession of cellular phone able to receive text messages

You may not qualify if…

• Use of assisted-walking devices
• Comorbid condition that would limit the ability to reduce sedentary behavior (e.g., musculoskeletal condition, current chemotherapy)
• Plans for major surgery within next 3 months
• Recent history (<1 year) of ischemic heart disease, chronic heart failure, stroke, or chronic kidney disease
• Recent (< 1 year) or planned bariatric surgery
• Systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg
• Current or recent (within last 6 months) pregnancy; current or recent (within last 3 months) breastfeeding
• Morbidly obesity (BMI >40 kg/m\^2) or underweight (BMI <18.5 kg/m\^2)
• Use of anti-hypertensive drugs
• Use of glucose-controlling medication
• Heavy alcohol consumption (>15 drinks per week)

Where it is running

• University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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