Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1-Mediated Proteinuric Kidney Disease

Recruiting now · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Proteinuric Kidney Disease

In brief

The purpose of this study is to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of VX-147 in adult and pediatric participants with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease.

Key facts

Study ID

NCT05312879

Run by

Vertex Pharmaceuticals Incorporated

People needed

466

Starts

2022-03-30

Expected to finish

2030-05-07

Last updated by the study team

2026-08-04

Who can join

Age: 10 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Nephrology & Hypertension Associates, PC — Middlebury, Connecticut, United States (enrolling)
• The George Washington University - GW Medical Faculty Associates — Washington D.C., District of Columbia, United States (enrolling)
• Children's Hospital of Alabama — Birmingham, Alabama, United States (enrolling)
• Greater Hartford Nephrology — Bloomfield, Connecticut, United States (enrolling)
• Yale University - Yale Nephrology Clinical Research Clinic — New Haven, Connecticut, United States (enrolling)
• Children's National Hospital - Nephrology — Washington D.C., District of Columbia, United States (enrolling)
• Nephrology Consultants, LLC — Huntsville, Alabama, United States (enrolling)
• Renal Associates of Alabama, LLC — Montgomery, Alabama, United States (enrolling)
• EmVenio Research - Mobile Unit - Birmingham — Birmingham, Alabama, United States (enrolling)
• Arizona Kidney Disease and Hypertension Center - Thomas Office — Phoenix, Arizona, United States (enrolling)
• Nephrology Associates — Fairhope, Alabama, United States (enrolling)
• Alabama Kidney Research — Alabaster, Alabama, United States (enrolling)
• Heart Center Research LLC — Huntsville, Alabama, United States (enrolling)
• The Medical Research Group - Saint Agnes Medical Center — Fresno, California, United States (enrolling)
• Amicis Research Center - Balboa — Granada Hills, California, United States (enrolling)
• Kidney Care Center of North Valley — Granada Hills, California, United States (enrolling)
• Eastside Clinical Research Associates — Los Angeles, California, United States (enrolling)
• Kaiser Permanente Los Angeles Medical Center — Los Angeles, California, United States (enrolling)
• Cedars-Sinai Medical Center — Los Angeles, California, United States (enrolling)
• The Kirklin Clinic - Nephrology — Birmingham, Alabama, United States (enrolling)
• UCI Center for Clinical Research — Orange, California, United States (enrolling)
• Kaiser Permanente Sacramento Medical Center — Sacramento, California, United States (enrolling)
• Helen Diller Medical Center at Parnassus Heights — San Francisco, California, United States (enrolling)
• UCLA Lundquist Institute at Harbor-UCLA Medical Center — Torrance, California, United States (enrolling)
• Veterans Affairs Medical Center - Washington D.C — Washington D.C., District of Columbia, United States (enrolling)

Full record on ClinicalTrials.gov

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