Optimizing Cerebral Autoregulation During Surgery

Completed · Not applicable

Conditions studied: Hip Fractures, Hip Arthropathy, Surgery, Delirium

In brief

The purpose of this study is to conduct a pilot trial to determine the feasibility, safety, and potential efficacy of targeting mean arterial blood pressure (MAP) within the limits of cerebral autoregulation during surgery compared with usual care.

Key facts

Study ID

NCT05308290

Run by

Johns Hopkins University

People needed

27

Starts

2023-01-09

Expected to finish

2025-07-30

Last updated by the study team

2025-09-02

Who can join

Age: 60 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• planned hip or knee surgery (either for fracture or elective) or lung surgery
• age ≥60
• ambulatory at baseline
• expected duration of surgery > 90 minutes

You may not qualify if…

• Planned concurrent surgery
• Allergy to adhesive tape
• Short Blessed Test score >20
• Clinical diagnosis of dementia
• Opinion of either the anesthesiologist or surgeon that the patient is not appropriate.

Where it is running

• The Johns Hopkins University — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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